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Rodica, 19 years from South-Eastern Europe
Rodica's ALEX³ test results
Allergen source
Allergen
Biochemical designation
IgE Level [kUA/L]
Timothy grass
Phl p 1
β-Expansin
3.79
Timothy grass
Phl p 2
Expansin
1.57
Timothy grass
Phl p 12
Profilin
2.14
Ragweed
Amb a 1
Pectate lyase
0.89
Ragweed
Amb a 4
Defensin-like protein
0.62
Mugwort
Art v 1
Defensin-like protein
0.78
Mugwort
Art v 3
nsLTP
0.61
Ribwort
Pla l 1
Ole e 1 family
0.61
Allergen source
Allergen
Biochemical designation
IgE Level [kUA/L]
Apple
Mal d 3
nsLTP
0.60
Kiwi
Act d 10
nsLTP
0.99
Peach
Pru p 3
nsLTP
1.18
Muskmelon
Cuc m 2
Profilin
1.89
Hen's egg
Gal d 2
Ovalbumin
0.37
Analysis
Grass pollen
- Sensitisation to Phl p 1 and 2 confirms genuine grass pollen allergy
- Profilin sensitisation: Phl p 12 explains broad fruit extract positives (e.g., melon, citrus) with usually mild OAS
Weed pollen
- Genuine ragweed, mugwort, ribwort allergy
Fruit and hen's egg
- Emerging nsLTP sensitisation at low-moderate IgE was found for apple, kiwi and peach
- The sensitisation to Gal d 2 from hen’s egg seems to be an immunological remnant from childhood - no clinical reactions were observed to hen’s egg since then.
Summary
- SPT findings were confirmed at the molecular level: genuine grass and weed pollinosis plus a profilin syndrome (Phl p 12, Cuc m 2) that accounts for many fruit-related oral symptoms.
- Low–moderate nsLTP reactivity (Pru p 3, Mal d 3, Act d 10) indicates an emerging LTP pattern that may progress beyond OAS, particularly with co-factors like exercise, alcohol, NSAIDs
- AIT for grass (Phl p 1/2) and (if clinically indicated) ragweed/mugwort is appropriate for respiratory disease
- Profilin-related food is often tolerated when cooked, mild symptoms
- Caution for LTP-rich foods (peach/stone fruits, kiwi, some nuts) and co-factors
- Because vomiting has occurred and LTPs are present, emergency kit is advised and individualised avoidance
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