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Henrik, 13 years from Finland
Henrik's ALEX³ test results
Allergen source
Allergen
Biochemical designation
IgE Level [kUA/L]
Pig
Sus d 1
Serum Albumin
2.12
Dog
Can f 3
Serum Albumin
0.44
Cat
Fel d 1
Uteroglobin
9.45
Cat
Fel d 2
Serum Albumin
4.72
Analysis
Cross-reactions
- Sensitisation to highly cross-reactive serum albumins was detected
True cat allergy
- Fel d 1-positivity reflects true cat allergy
Cat-pork-syndrome
- Fel d 2 sensitisation can lead to cat-pork syndrome: clinically relevant cross-reactivity may occur when eating raw pork (ham, salami) or not fully cooked pork
Summary
- Sensitisation to cat and dog has been identified
- Henrik is also sensitised to serum albumins, which are responsible for cross-reactions with albumins in meat and milk
- An example for this kind of cross-reaction is the cat-pork syndrome
- Since serum albumins are thermolabile proteins, thoroughly cooked meat is usually well tolerated
- Patient education on avoidance measures is advised
- Heat treatment (frying, boiling, etc.) or other procedures such as freeze-drying can reduce the allergenicity of pork in serum albumin-associated pork allergy
- Henrik should continue to avoid contact with cats.
Novel findings revealed by ALEX³
- Sensitised to cat epithelia
- Due to strong cross-reactivity of serum albumins, sensitisation to dog and pork could also be detected
- Cat-pork-syndrome
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